PD-1/PD-L1-IN 6

立即咨询

PD-1/PD-L1-IN 6

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2393983-76-9

PD-1/PD-L1-IN 6 (compound A13) 是一种有效的PD-1/PD-L1相互作用抑制剂，其IC₅₀为 132.8 nM。PD-1/PD-L1-IN 6 具有显著的免疫调节活性。PD-1/PD-L1-IN 6 在 Hep3B/OS-8/hPD-L1 与 CD3 T细胞共培养模型中显著提高干扰素 -γ 分泌，且无明显毒性作用。PD-1/PD-L1-IN 6 在 T 细胞-肿瘤共培养模型中恢复免疫应答。

生物活性	PD-1/PD-L1-IN 6 (compound A13) is a potentPD-1/PD-L1interaction inhibitor, with anIC₅₀of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model^[1].
IC₅₀& Target	IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)
分子量	402.49
Formula	C₂₅H₂₆N₂O₃
CAS 号	2393983-76-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.