IC 86621

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IC 86621

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

404009-40-1

IC 86621 是一种有效的 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂，其IC₅₀为 120 nM。IC 86621 还可作为选择性和可逆的ATP竞争性抑制剂。IC 86621 可抑制 DNA-PK 介导的细胞 DNA 双链断裂 (DSB) 修复 (EC₅₀=68 μM)。IC 86621 可增加 DSB 诱导的抗肿瘤活性，但没有细胞毒性作用。IC 86621 可防止类风湿关节炎 (RA) T 细胞凋亡 (apoptosis)。

生物活性

IC 86621 is a potentDNA-dependent protein kinase (DNA-PK)inhibitor, with anIC₅₀of 120 nM. IC 86621 also acts as a selective and reversibleATP-competitive inhibitor.IC 86621 inhibitsDNA-PKmediated cellular DNA double-strand break (DSB) repair (EC₅₀=68 μM). IC 86621 increases DSB-inducedantitumoractivity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells fromapoptosis^[1]^[2].

IC₅₀& Target

IC50: 120 nM (DNA-PK)^[1]

体外研究
(In Vitro)

IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12^[1].
IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis^[2].

Apoptosis Analysis^[2]

Cell Line:	CD4⁺CD45RO^-T cells (from six control donors and seven RA patients)
Concentration:	0 nM, 50 nM, 100 nM
Incubation Time:	24 h
Result:	Protected RA (rheumatoid arthritis) T cells from apoptosis.

分子量

221.25

Formula

C₁₂H₁₅NO₃

CAS 号

404009-40-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.