QL9 (QLSPFPFDL) is a high-affinity alloantigen for the 2C T cell receptor (TCR).

TCR^[1]

Mouse T cell clone 2C recognizes two different major histocompatibility (MHC) ligands, the self MHC K^band the allogeneic MHC L^d. Two distinct peptides, SIY (SIYRYYGL) and QL9 (QLSPFPFDL), act as strong and specific agonists when bind to K^band L^d, respectively. QL9 binding to MHC L^dis influenced by the majority of peptide side chains, distributed across the entire length of the peptide. Findings with both systems, but QL9-L^din particular, suggest that many single-residue substitutions, introduced into peptides to improve their binding to MHC and thus their vaccine potential, could impair T cell reactivity due to their dual impact on TCR binding. T cell activation assays are performed to measure effects of peptide SIY and QL9 residues on T cell function^[2].

1063.21

Solid

C₅₂H₇₄N₁₀O₁₄

159646-83-0

Gln-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu

QLSPFPFDL

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 33.33 mg/mL(31.35 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。