Myelin Oligodendrocyte Glycoprotein Peptide(35-55),mouse,rat acetate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

MOG (35-55) (acetate)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) acetate 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 有致脑炎活性，诱导 T 细胞增殖。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 诱导 Th1 细胞因子反应以及相对高水平的 IgG 抗体产生。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate 引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。

生物活性

Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat (MOG (35-55)) acetate is a minor component of CNS myelin. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat acetate has encephalitogenic activity and induces T cell proliferative. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat acetate induces Th1 cytokine response as well as relatively high levels ofIgGantibodies. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat acetate produces a relapsing-remittingneurological diseasewith extensive plaque-like demyelination^[1]^[2]^[3].

体外研究
(In Vitro)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 0-50 μg/mL; 72 h; lymph nodes cells) acetate induces T cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate increases the level of IgG^[1].

体内研究
(In Vivo)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 200 μg (0.2 mL); i.p.; once, for 38 d) acetate has encephalitogenic activity in HLA-DR2 (DRB1*1501) mice^[1].

Animal Model:	HLA-DR2 (DRB1*1501) mice^[1]
Dosage:	200 μg (0.2 mL)
Administration:	Intraperitoneal injection; once, for 38 days
Result:	Resulted in paralysis of both hind and forelimbs.

分子量

2642.00

性状

Solid

Formula

C₁₂₀H₁₈₁N₃₅O₃₁S

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(37.85 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.3785 mL	1.8925 mL	3.7850 mL
5 mM	0.0757 mL	0.3785 mL	0.7570 mL
10 mM	0.0379 mL	0.1893 mL	0.3785 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。