Myelin Oligodendrocyte Glycoprotein Peptide(35-55),mouse,rat TFA

位置：首页 > 产品库 > Myelin Oligodendrocyte Glycoprotein Peptide(35-55),mouse,rat TFA

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

MOG (35-55) (TFA)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA 有致脑炎活性，诱导 T 细胞增殖。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA 诱导 Th1 细胞因子反应以及相对高水平的 IgG 抗体产生。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA 引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。

生物活性

Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat (MOG (35-55)) TFA is a minor component of CNS myelin. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat TFA has encephalitogenic activity and induces T cell proliferative. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat TFA induces Th1 cytokine response as well as relatively high levels ofIgGantibodies. Myelin OligodendrocyteGlycoproteinPeptide (35-55), mouse, rat TFA produces a relapsing-remittingneurological diseasewith extensive plaque-like demyelination^[1]^[2]^[3].

体外研究
(In Vitro)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 0-50 μg/mL; 72 h; lymph nodes cells) TFA induces T cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA increases the level of IgG^[1].

体内研究
(In Vivo)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 200 μg (0.2 mL); i.p.; once, for 38 d) TFA has encephalitogenic activity in HLA-DR2 (DRB1*1501) mice^[1].

Animal Model:	HLA-DR2 (DRB1*1501) mice^[1]
Dosage:	200 μg (0.2 mL)
Administration:	Intraperitoneal injection; once, for 38 days
Result:	Resulted in paralysis of both hind and forelimbs.

分子量

2695.97

性状

Solid

Formula

C₁₂₀H₁₇₈F₃N₃₅O₃₁S

Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys

Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light, stored under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

H₂O : ≥ 50 mg/mL(18.55 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.3709 mL	1.8546 mL	3.7092 mL
5 mM	0.0742 mL	0.3709 mL	0.7418 mL
10 mM	0.0371 mL	0.1855 mL	0.3709 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light, stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (37.09 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。