TSR-033 is a high affinity humanIgG4antibody targetingLAG-3(lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed withPD-1, that enhances T cell function andPD-1blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity^[1].

TSR-033 (0.01-1000 nmol/L, 48 h) 可以增加原代人类 CD4 T细胞和树突状细胞的 IL2 产生，并增强T细胞效应器功能^[1]。

TSR-033 (i.p.,10 mg/kg, twice weekly, 40 days) 在 A549 HuNOG-EXL NSCLC 小鼠肿瘤模型中，对肿瘤生长有中等程度的抑制作用，单独治疗终止时TGI 为 23%，而与 TSR-042 联合治疗有累积效应，能更大程度地阻碍肿瘤生长，终止时 TGI 为 45%^[1]。

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