BAY-784

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BAY-784

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1631164-24-3

BAY-784 是一种促性腺激素释放激素受体 (GnRH-R) 拮抗剂探针，对人和大鼠GnRH-R的IC₅₀分别为 21 和 24 nM。

生物活性

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe withIC₅₀s of 21 and 24 nM for human and rat GnRH-R, respectively^[1].

IC₅₀& Target

IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)^[1]

体内研究
(In Vivo)

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner^[1].

Animal Model:	OVX rats^[1]
Dosage:	0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration:	Single p.o.
Result:	ED₅₀=4.5 mg/kg (4/8 h). The t_1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.

分子量

672.11

Formula

C₂₉H₂₆ClF₄N₃O₅S₂

CAS 号

1631164-24-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.