Histrelin

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Histrelin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

76712-82-8

组氨瑞林

Histrelin，一种 GnRH 类似物，是一种GnRH受体激动剂。Histrelin 可增加血清中促黄体激素(LH)、促卵泡激素 (FSH) 和睾酮水平。Histrelin 可用于前列腺癌、子宫内膜异位症的研究。

生物活性

Histrelin, a GnRH analogue, is aGnRH Receptoragonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostatecancer, endometriosis^[1]^[2]^[5].

IC₅₀& Target

GnRH Receptor^[1]

体外研究
(In Vitro)

Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants^[4].
Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system^[5].

体内研究
(In Vivo)

Histrelin (0.1 mg/kg, subcutaneous injection) rescues the circulating LH concentrations inCsfm^op/Csfm^opmice^[2].
Histrelin (10,30, or 100 μg /day, subcutaneous injection) reduces the number of endometrial glands and atrophied the stroma in rabbits^[3].

Animal Model:	Csfm^op/Csfm^opmice^[2]
Dosage:	0.001, 0.05, and 0.1 mg/kg
Administration:	Subcutaneous injection
Result:	Increased serum FSH concentrations by 4-fold.

Animal Model:	Rabbits^[3]
Dosage:	10, 30, or 100 μg /day
Administration:	Subcutaneous injection for 4 weeks
Result:	Caused a regression of the endometrial glands and a thinning of the stroma.

Clinical Trial

分子量

1323.50

Formula

C₆₆H₈₆N₁₈O₁₂

CAS 号

76712-82-8

中文名称

组氨瑞林

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.