Antide

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Antide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

112568-12-4

D-21074
ORF 23541

Antide (D-21074) 是一种有效的LHRH拮抗剂。Antide 也可用于前列腺癌的研究。

生物活性

Antide (D-21074) is a potentLHRHantagonist. Antide also can be used for the research of prostaticcancer.

体内研究
(In Vivo)

Antide (subcutaneously; 1, 3, 6, 10 and 15 mg/kg; once or on 5 consecutive days) can induce a long-term chemical castration in adult male rats and cynomolgus monkeys^[1].

Animal Model:	Cynomolgus monkey and rat^[1]
Dosage:	1, 3, 6, 10 and 15 mg/kg
Administration:	Subcutaneous, once or on 5 consecutive days
Result:	Had a dose-dependent inhibitory effect on serum concentration of LH (only rat) and testosterone and on the weights of the testes, prostates and seminal vesicles. Achieved long-lasting castration-like effects at concentrations between 6 (less than or equal to 8 weeks) and 15 mg/kg (greater than 8 weeks) in the rat. Induced a prolonged inhibitory effect only at 15 mg/kg and the duration was only 2-3 weeks in the cynomolgus monkey.

分子量

1591.29

Formula

C₈₂H₁₀₈ClN₁₇O₁₄

CAS 号

112568-12-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.