Cetrorelix diacetate

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CAS NO:

130143-01-0

SB-75 diacetate

Cetrorelix diacetate (SB-075 diacetate)是GnRH受体的强效拮抗剂，其IC₅₀值为 1.21 nM。

生物活性

Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone(GnRH)receptor antagonist with anIC₅₀of 1.21 nM^[1].

IC₅₀& Target

IC50: 1.21 nM GnRH^[1].

体外研究
(In Vitro)

Cetrorelix diacetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix diacetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells^[2].

Clinical Trial

分子量

1551.14

Formula

C₇₄H₁₀₀ClN₁₇O₁₈

CAS 号

130143-01-0

Sequence Shortening

Ac-{2-Naph-Ala}-{Cl-Phe}-{3Py-Ala}-SY-{Cit}-LRPA-NH2

中文名称

二醋酸西曲瑞克

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.