hDHODH-IN-11

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hDHODH-IN-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2396653-34-0

hDHODH-IN-11 是一种有效的人二氢旋转酸脱氢酶 (hDHODH) 抑制剂，其IC₅₀值为 7.2 nM。hDHODH-IN-11具有低细胞毒性。hDHODH-IN-11 可用于急性髓系白血病 (AML) 的研究。

生物活性

hDHODH-IN-11 is a potent humandihydroorotate dehydrogenase(hDHODH)inhibitor with anIC₅₀value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML)^[1].

IC₅₀& Target

IC50: 7.2 nM (hDHODH)^[1]

体外研究
(In Vitro)

hDHODH-IN-11 (0.1 and 1 μM; 72 h; THP1 and U937 cells) has low cytotoxicity, pro-apoptotic and pro-differentiating abilities^[1].
hDHODH-IN-11 (0.1 μM; 72 h; THP1 and MV4-11 cells) withDipyridamole(HY-B0312) results in synergistic effect and demonstrates a good pro-apoptotic activity^[1].

体内研究
(In Vivo)

hDHODH-IN-11 (20 mg/kg; i.p.; daily, for 13 d; Balb/c mice with AML xenografts) reduces the leukemic burden and tumor weight^[1].

Animal Model:	Balb/c mice with AML xenografts^[1]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection; daily, for 13 days
Result:	Reduced the leukemic burden and tumor weight.

分子量

401.46

Formula

C₂₄H₂₃N₃O₃

CAS 号

2396653-34-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.