HDAC-IN-27 (Compound 11h) is a potent, selective and orally activeHDACClass I inhibitor, with IC₅₀values ranging from 0.43 nM to 3.01 nM for HDAC1-3. HDAC-IN-27 shows anti-acute myeloid leukemia (AML) activity^[1].

In wt-p53 MV4-11 cells, HDAC-IN-27 (11h) leads to pro-caspase-3 cleavage, apparent apoptotic cell death, and accumulation of sub-G1 cell population while inducing G2/M arrest in HL60 cells with no evidence of apoptosis^[1].

350.41

C₂₀H₂₂N₄O₂

Room temperature in continental US; may vary elsewhere.

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