DD1

立即咨询

DD1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

187585-11-1

DD1 是一种蛋白酶体 (proteasome) 抑制剂，在急性髓细胞白血病 (AML) 凋亡过程中，激活 Bax，降解 P70S6K。DD1 以 caspase 依赖性方式诱导细胞凋亡。DD1 诱导线粒体膜去极化和 Bad 去磷酸化。

生物活性

DD1, aproteasomeinhibitor, targetsBaxactivation andP70S6Kdegradation during acute myeloid leukemia (AML)apoptosis. DD1 inducesapoptosisin the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation^[1].

IC₅₀& Target

p70S6K

体外研究
(In Vitro)

DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells^[1].
DD1 induces cell cycle arrest at G2/M phase and apoptosis^[1].
DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation^[1].
DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates^[1].

分子量

282.29

Formula

C₁₆H₁₄N₂O₃

CAS 号

187585-11-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.