FLT3-IN-11

立即咨询

FLT3-IN-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2499966-50-4

FLT3-IN-11 (compound 30) 是一种有效、选择性和具有口服活性的FLT3激酶抑制剂，对野生型FLT3和FLT3-D835Y的IC₅₀分别为 7.22 nM 和 4.95 nM。FLT3-IN-11 对FLT3的选择性高于 c-KIT (>1000 倍)。FLT3-IN-11 具有出色的抗急性髓性白血病 (AML) 活性 (MV4-11 细胞，IC₅₀为 3.2 nM)。

生物活性	FLT3-IN-11 (compound 30) is a potent, selective and orally activeFLT3kinase inhibitor withIC₅₀s of 7.22 nM and 4.95 nM forwild-typeFLT3andFLT3-D835Y, respectively. FLT3-IN-11 high selectivity forFLT3overc-KIT(>1000-fold). FLT3-IN-11has excellent anti-acute myeloid leukemia (AML) activity (MV4-11 cells, IC₅₀of 3.2 nM)^[1].
IC₅₀& Target	IC50: 7.22 nM (wild-type FLT3) and 4.95 nM (FLT3-D835Y)^[1]
体外研究 (In Vitro)	FLT3-IN-11 (compound 30) efficiently inhibits the growth of multiple mutant BaF3 cells expressing FLT3-ITD, FLT3-D835V/F, FLT3-F691L, FLT3-ITD-F691L, and FLT3-ITD-D835Y^[1].
体内研究 (In Vivo)	Oral administration of FLT3-IN-11 (compound 30) at 6 mg/kg/d could significantly suppress tumor growth in the MV4-11 cell-inoculated xenograft model, exhibiting tumor growth inhibitory rates of 83.5%^[1].
分子量	422.45
Formula	C₂₀H₂₅F₃N₆O
CAS 号	2499966-50-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.