Tallimustine

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Tallimustine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

115308-98-0

FCE 24517

Tallimustine (FCE 24517)，一种 distamycin-A 衍生物，是一种抗癌剂。

生物活性

Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent^[1]^[2]^[4].

体外研究
(In Vitro)

Tallimustine (0.1-10 μM, 4 h) induces damage to purified SV40 DNA^[1].
Tallimustine (72 h ) shows cytotoxicity in CEM Cells, with an IC₅₀of 3.5 nM^[1].
Tallimustine (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells^[2].
Tallimustine (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells^[2].
Tallimustine (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase^[3].

Cell Viability Assay^[2]

Cell Line:	K562 cells
Concentration:	25 and 100 nM
Incubation Time:	4 days
Result:	Inhibited cell proliferation.

体内研究
(In Vivo)

Tallimustine (3 mg/kg, i.p.) shows antileukaemic activity in L1210 tumor bearing mice^[4].

Animal Model:	L1210 tumor bearing mice^[2].
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Prolonged the survival of mice.

Clinical Trial

分子量

697.61

Formula

C₃₂H₃₈Cl₂N₁₀O₄

CAS 号

115308-98-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.