Imipramine-d4 hydrochloride

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CAS NO:

61361-33-9

盐酸丙咪嗪 d4 (盐酸盐)

Imipramine-d4 hydrochloride 是 Imipramine hydrochloride 的氘代物。Imipramine hydrochloride 是一种具有口服活性的叔胺类三环抗抑郁药。Imipramine hydrochloride 是一种具有抗肿瘤活性的Fascin1抑制剂。Imipramine hydrochloride 也抑制 5-羟色胺转运体 (serotonin transporter)，其IC₅₀值为 32 nM。Imipramine hydrochloride 刺激 U-87MG 胶质瘤细胞自噬（autophagy），诱导 HL-60 细胞凋亡（apoptosis）。Imipramine hydrochloride 具有神经保护和免疫调节作用。

生物活性	Imipramine-d4 hydrochloride is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is aFascin1inhibitor with antitumor activities. Imipramine hydrochloride also inhibitsserotonin transporterwith anIC₅₀value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cellsautophagyand induces HL-60 cellapoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects^[1]^[2]^[3]^[4]^[5]^[6].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
分子量	320.89
性状	Solid
Formula	C₁₉H₂₁D₄ClN₂
CAS 号	61361-33-9
中文名称	盐酸丙咪嗪 d4 (盐酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)