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S-(N-PhenethylthiocarbaMoyl)-L-cysteine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
S-(N-PhenethylthiocarbaMoyl)-L-cysteine图片
CAS NO:53330-02-2

PEITC-Cys
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) 是一种抗癌物质 (anticarcinogenic)，具有抗白血病活性。S-(N-PhenethylthiocarbaMoyl)-L-cysteine 抑制 HL60 细胞的 DNA 合成。S-(N-PhenethylthiocarbaMoyl)-L-cysteine 是P450抑制剂。
生物活性

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), ananticarcinogenicagent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is aP450inhibitor[2].

IC50& Target

DNA Synthesis[1]; P450[2]

体外研究
(In Vitro)

S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits cell growth of HL60 cell (GC50=336 nM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells (IC50=6.47 μM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine induced DNA fragmentation in HL 60 cells[1].

Cell Proliferation Assay[1]

Cell Line:HL60 cells
Concentration:0.1-10 μM
Incubation Time:48 hours
Result:Inhibited the cell growth with a GC50value of 336 nM.

Cell Proliferation Assay[1]

Cell Line:HL60 cells
Concentration:4 μM
Incubation Time:0, 20, 40, 60, 80, 100 hours
Result:Inhibited the cell growth.
分子量

284.40

Formula

C12H16N2O2S2

CAS 号

53330-02-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

 
 
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