PI3K-IN-29

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PI3K-IN-29

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

PI3K-IN-29 是一种有效的PI3K抑制剂。PI3K-IN-29 对 U87MG、HeLa 和 HL60 细胞具有较好的抑制作用，IC₅₀值分别为 0.264、2.04 和 1.14 μM。PI3K-IN-29 通过抑制PI3K催化的Akt的磷酸化来抑制PI3K/Akt通路。

生物活性

PI3K-IN-29 is a potentPI3Kinhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀values of 0.264, 2.04 and 1.14 μM, respectively. PI3K-IN-29 inhibitsPI3K/Aktpathway by inhibiting phosphorylation ofAktthat is catalyzed byPI3K^[1].

体外研究
(In Vitro)

PI3K-IN-29 (compound 25) (72 h) displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀values of 0.264, 2.04 and 1.14 μM, respectively^[1].
PI3K-IN-29 (U87MG cells; 1, 5 μM; 1 h) inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K^[1].

Cell Proliferation Assay^[1]

Cell Line:	U87MG, HeLa, HepG2, A549, HL60, MCF7 cells
Concentration:
Incubation Time:	72 h
Result:	Displayed good inhibition potencies against U87MG, HeLa and HL60 cells with IC₅₀values of 0.264, 2.04 and 1.14 μM, respectively.

Western Blot Analysis^[1]

Cell Line:	U87MG cells
Concentration:	1, 5 μM
Incubation Time:	1 h
Result:	Inhibited PI3K/Akt pathway by inhibiting phosphorylation of Akt that was catalyzed by PI3K.

分子量

560.03

Formula

C₂₇H₂₂ClN₇O₃S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.