NADH-IN-1

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NADH-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1432445-15-2

NADH-IN-1 对NADH: 泛醌氧化还原酶 (NADH:ubiquinone oxidoreductase)具有抑制活性，IC₅₀为 27 μM。NADH-IN-1 在体外能有效刺激葡萄糖摄取。NADH-IN-1易被肝脏代谢。可用于糖尿病的研究。

生物活性

NADH-IN-1 hasNADH:ubiquinone oxidoreductaseinhibitory activity with anIC₅₀value of 27 μM. NADH-IN-1 can effectively stimulate glucose uptakein vitro. NADH-IN-1 is readily metabolised by the liver. NADH-IN-1 can be used for researching diabetes^[1].

IC₅₀& Target

IC₅₀: 27 μM (NADH:ubiquinone oxidoreductase)^[1]

体内研究
(In Vivo)

NADH-IN-1 (1 μM) exhibits a short half-life and fast intrinsic clearance indicating that it is readily metabolised by the liverin vivo; shows no adverse effects on primary rat hepatocytes, and does not inhibit the hERG channel^[1].
NADH-IN-1 (10 mg/kg; IV or PO; single dosage) produces no observable toxic effects at 10 mg/kg by IV or PO; exhibits a short half-life and high plasma clearance; exhibits high mouse and human serum protein binding, as well as moderate bioavailability^[1].

Animal Model:	Male C57BL/6 mice^[1]
Dosage:	10 mg/kg
Administration:	IV or PO; single dosage (Pharmacokinetics Analysis)
Result:	Produced no observable toxic effects at 10 mg/kg by IV or PO; exhibited a short half-life of 0.45 h and high plasma clearance; exhibited high mouse and human serum protein binding, as well as moderate bioavailability (21.4%).

分子量

382.44

Formula

C₁₉H₂₁F₃N₂OS

CAS 号

1432445-15-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.