CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity forPLK4(IC₅₀of 0.6 nM)^[1].

CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB231 cell growth^[1].
CFI-400437 inhibits Aurora A, Aurora B, KDR and FLT-3 with IC₅₀s of 0.37, 0.21, 0.48, and 0.18 μM, respectively, i.e. two orders of magnitude higher than its IC₅₀of 0.6 nM against PLK4^[1].
CFI-400437 inhibits both AURKB and AURKC at concentrations<15 nm^[2].

CFI-400437 (25 mg/kg, ip, once daily for 21 d) exhibits antitumor activity against MDA-MB-468 breast cancer mouse xenograft model^[1].

492.57

C₂₉H₂₈N₆O₂

1169211-37-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.