首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > Dapsone
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Dapsone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dapsone图片
CAS NO:80-08-0
包装:1mg
市场价:1187元

氨苯砜（4,4'-二氨基二苯砜）是一种具有口服活性和血脑渗透性磺胺类抗生素，具有抑菌、抗分枝杆菌和抗原生动物活性。
Cas No.80-08-0
别名氨苯砜; 4,4′-Diaminodiphenyl sulfone; DDS
化学名4,4'-sulfonyldianiline
Canonical SMILESNC1=CC=C(S(C2=CC=C(N)C=C2)(=O)=O)C=C1
分子式C12H12N2O2S
分子量248.3
溶解度≥ 8.35mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.Target: AntibacterialDapsone is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). Dapsone antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects [1]. As an antibacterial, dapsone inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Dapsone has anti-inflammatory and immunomodulatory effects [2].

References:
[1]. Diaz-Ruiz, A., et al., Antioxidant, antiinflammatory and antiapoptotic effects of dapsone in a model of brain ischemia/reperfusion in rats. J Neurosci Res, 2008. 86(15): p. 3410-9.
[2]. Begon, E., O. Chosidow, and P. Wolkenstein, [Disulone]. Ann Dermatol Venereol, 2004. 131(12): p. 1062-73.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024