Leriglitazone hydrochloride

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CAS NO:	146062-46-6
包装:	5mg
市场价:	7700元

Hydroxypioglitazone hydrochloride

Leriglitazone (Hydroxypioglitazone) hydrochloride，吡格列酮的代谢产物。Leriglitazone (Hydroxypioglitazone) hydrochloride是PPARγ激动剂，通过稳定 PPARγ (AF-2) 共激活剂结合表面和增强共激活剂结合能力，提供高转录效力。 Leriglitazone (Hydroxypioglitazone) hydrochloride 与 PPARγC (LBD) 结合，其K_i值为 1.2 μM，诱导 PPARγ (LBD) 转录效率，EC₅₀为 680 nM。

生物活性

Leriglitazone (Hydroxypioglitazone) hydrochloride, a metabolite of pioglitazone. Leriglitazone (Hydroxypioglitazone) hydrochloride PioOH is aPPARγagonist, stabilizes thePPARγactivation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy. Leriglitazone (Hydroxypioglitazone) hydrochloride binds to thePPARγC-terminal ligand-binding domain (LBD) with aK_iof 1.2 μM，Leriglitazone induces transcriptional efficacy of thePPARγ(LBD) with anEC₅₀of 680 nM^[1].

IC₅₀& Target^[1]

PPAR-γ

分子量

408.90

性状

Solid

Formula

C₁₉H₂₁ClN₂O₄S

CAS 号

146062-46-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 50 mg/mL(122.28 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.4456 mL	12.2279 mL	24.4559 mL
5 mM	0.4891 mL	2.4456 mL	4.8912 mL
10 mM	0.2446 mL	1.2228 mL	2.4456 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。