CP-868388 free base

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CP-868388 free base

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

702681-67-2

CP-868388 free base 是一种有效的，选择性的，具有口服活性的PPARα激动剂，K_i值为 10.8 nM。CP-868388 free base 对 PPARβ (K_i为 3.47 μM) 和 PPARγ 几乎没有亲和力，具有降血脂和抗炎作用。

生物活性

CP-868388 free base is a potent, selective and orally activePPARαagonist with aK_ivalue of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (K_iof 3.47 μM) andPPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions^[1].

IC₅₀& Target^[1]

hPPARα

10.8 nM (Ki)

hPPARγ

3.47 μM (Ki)

体外研究
(In Vitro)

CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC₅₀of 4.7 nM) and PGC-1α peptide^[1].
CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC₅₀of 18 nM in HepG2 cells^[1].

体内研究
(In Vivo)

CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%^[1].

Animal Model:	Male B6/CBF1J mice^[1]
Dosage:	0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral gavage; once daily; for 2 days
Result:	Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.

分子量

439.54

性状

Solid

Formula

C₂₆H₃₃NO₅

CAS 号

702681-67-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 125 mg/mL(284.39 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2751 mL	11.3755 mL	22.7511 mL
5 mM	0.4550 mL	2.2751 mL	4.5502 mL
10 mM	0.2275 mL	1.1376 mL	2.2751 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。