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Tolnaftate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tolnaftate图片
CAS NO:2398-96-1
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)询价
50mg询价

Tolnaftate (NP-27) 是一种合成的硫代氨基甲酸酯，用作抗真菌剂。
Cas No.2398-96-1
别名托萘酯; NP-27
化学名O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
Canonical SMILESCC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2
分子式C19H17NOS
分子量307.41
溶解度≥ 12.7mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .

Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans[1]. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid[2].

References:
[1]. Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29(5): p. 858-60.
[2]. Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36(8): p. 1779-81.

 
 
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