Topoisomerase I inhibitor 3

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CAS NO:

2588211-50-9

Topoisomerase I inhibitor 3 (Compound ZML-14) 是一种拓扑异构酶I（topoisomerase I）抑制剂。可与拓扑异构酶 I-DNA 复合物相互作用。Topoisomerase I inhibitor 3 诱导 HepG2 细胞凋亡（apoptosis），使细胞周期阻滞在 G2/M 期。

生物活性

TopoisomeraseI inhibitor 3 (Compound ZML-14) is atopoisomeraseIinhibitor and can interact withtopoisomeraseI-DNA complex.TopoisomeraseI inhibitor 3 induces HepG2 cellapoptosisand arrests cell cycle at G2/M phase^[1].

IC₅₀& Target

Topoisomerase I

体外研究
(In Vitro)

Topoisomerase I inhibitor 3 (Compound ZML-14) shows cytotoxicity with IC₅₀values of 1.94 ± 0.09, 10.32 ± 0.39, 13.1 ± 0.96, 40.69 ± 5.36, 28.11 ± 2.50, >100 and 37.42 ± 2.05 μM against HepG2, A2780, HeLa, HCT116, SW1990, MCF7 and L-02 cells, respectively^[1].

分子量

311.31

Formula

C₁₈H₁₄FNO₃

CAS 号

2588211-50-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.