Topoisomerase II inhibitor 11

首页蛋白库基因库产品会员服务

位置：首页 > 产品库 > Topoisomerase II inhibitor 11

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2476559-00-7

Topoisomerase II inhibitor 11 (compound 3d) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂，其IC₅₀为 2.89 μM。Topoisomerase II inhibitor 11 对肾癌 A498 细胞有 92.46% 的抑制作用，其IC₅₀值为 3.5 μM。Topoisomerase II inhibitor 11 在 G2/M 期引起细胞周期阻滞，导致细胞增殖抑制和促凋亡活性。

生物活性

TopoisomeraseII inhibitor 11 (compound 3d) is a potentTopoisomeraseIIinhibitor, with anIC₅₀of 2.89 μM.TopoisomeraseII inhibitor 11 shows 92.46% inhibition on renalcancercell line A498 with anIC₅₀of 3.5 μM.TopoisomeraseII inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition andpro-apoptoticactivity^[1].

IC₅₀& Target

Topoisomerase II

2.89 μM (IC₅₀)

分子量

588.34

Formula

C₂₇H₂₁BrCl₂N₂O₂S

CAS 号

2476559-00-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.