Topoisomerase II inhibitor 4 (compound E17) 是一种有效的拓扑异构酶 II (Topoisomerase II) 抑制剂。Topoisomerase II inhibitor 4 具有抗肿瘤作用，引起 G2/M 期细胞周期阻滞，抑制癌细胞增殖并显示出细胞毒性。
| 生物活性 | TopoisomeraseII inhibitor 4 (compound E17) is a potentTopoisomeraseIIinhibitor.TopoisomeraseII inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1]. |
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体外研究
(In Vitro) | Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1].
Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2].
Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2].
Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well[2].
Cell Migration Assay[2] | Cell Line: | HCT116, and WI-38 cells | | Concentration: | 0.4, 0.6, 0.8, 1.0, 1.2 μM | | Incubation Time: | 0, 12, 24, 48 hours | | Result: | Resulted migration inhibition in HCT116 and SW480 cells. |
Cell Viability Assay[2] | Cell Line: | HCT116, and WI-38 cells | | Concentration: | 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM | | Incubation Time: | 72 hours | | Result: | Exerted anti-proliferative effect in a dose-dependent manner. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
