Gly-Cyclopropane-Exatecan (compound 5c) 参与合成抗B7-H4抗体药物缀合物 (ADC)，含有 DNA 拓扑异构酶 I (Topoisomerase I) 抑制剂 Exatecan (HY-13631)。Gly-Cyclopropane-Exatecan 参与形成的 ADC 为 hu2F7-Exatecan (compound 34) 具有体内外抗肿瘤活性。
| 生物活性 | Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4ADC, containing Exatecan (HY-13631), a DNATopoisomeraseIinhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
