Topoisomerase II inhibitor 9

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CAS NO:

2413901-61-6

Topoisomerase II inhibitor 9 (Compound 19b) 是一种Topo II抑制剂，IC₅₀为 0.97 μM。Topoisomerase II inhibitor 9 也是一种 DNA 嵌入剂，IC₅₀为 43.51 μM。Topoisomerase II inhibitor 9 在 G2/M 期阻滞 Hep G‐2 细胞周期，诱导细胞凋亡 (apoptosis)。

生物活性

TopoisomeraseII inhibitor 9 (Compound 19b) is aTopo IIinhibitor with anIC₅₀of 0.97 μM.TopoisomeraseII inhibitor 9 is also a classical DNA-intercalator with anIC₅₀of 43.51 μM.TopoisomeraseII inhibitor 9 arrests the cell cycle at the G2/M phase and inducesapoptosisin Hep G‐2 cells^[1].

IC₅₀& Target

Topoisomerase II

0.97 μM (IC₅₀)

体外研究
(In Vitro)

Topoisomerase II inhibitor 9 (Compound 19b) shows antiproliferative activity with IC₅₀values of 0.50 ± 0.1, 0.75 ± 0.1 and 2.91 ± 0.1 μM against Hep G‐2, Hep‐2 and Caco‐2 cells, respectively^[1].

分子量

491.55

Formula

C₂₂H₁₇N₇O₃S₂

CAS 号

2413901-61-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.