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Urocortin(rat)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Urocortin(rat)图片
CAS NO:171543-83-2
包装:1mg
市场价:3245元

Urocortin (rat) (Urocortin (Rattus norvegicus)) 是一种神经肽和有效的内源性 CRFR 激动剂，对人 CRF1、大鼠 CRF2α 和小鼠 CRF2β 的 Kis 分别为 13 nM、1.5 nM 和 0.97 nM。
Cas No.171543-83-2
别名Urocortin (Rattus norvegicus); Rat urocortin;
Canonical SMILESCC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@]2([H])CCCN2C([C@](/N=C(O)/[C@](N)([H])CC(O)=O)([H])CC(O)=O)=O)=O)([H])CC(C)C)([H])CO)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@]
分子式C206H338N62O64
分子量4707.26
溶解度Formic Acid: 1 mg/ml
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for hCRF1, rCRF2α and mCRF2β, respectively.

Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively[1].

Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].

References:
[1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.
[2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.

 
 
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