Topo I-IN-1

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Topo I-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Topo I-IN-1 (Compound 14d) 是一种具有抗肿瘤活性和 DNA 嵌入能力的Topo I抑制剂。Topo I-IN-1 诱导细胞凋亡 (apoptosis)。

生物活性

Topo I-IN-1 (Compound 14d) is a potentTopo Iinhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cellapoptosis^[1].

IC₅₀& Target

Topoisomerase I

体外研究
(In Vitro)

Topo I-IN-1 (Compound 14d) (0-50 μM, 48 h) shows antiproliferative activity against human cancer cells and has low toxicity toward normal rat kidney epithelial cells^[1].
Topo I-IN-1 (0-4 μM, 48 h) shows a dose-dependent apoptotic effect, induces ROS generation, and inhibits cell migration^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	A549, HCT116, MCF7, SK-MEL-28, and NRK (normal rat kidney epithelial cells)
Concentration:	0-50 μM
Incubation Time:	48 h
Result:	Showed in vitro cytotoxicity with IC₅₀values of 2.33 ± 1.52, 2.85 ± 0.83, 26.23 ± 2.48, 3.86 ± 0.33, and 29.99 ± 0.95 μM against A549, HCT116, MCF7, SK-MEL-28, and NRK cells, respectively.

Apoptosis Analysis^[1]

Cell Line:	A549
Concentration:	2, 2.33 and 4 μM
Incubation Time:	48 h
Result:	Resulted in the morphological changes typical to apoptosis.

分子量

408.25

Formula

C₂₀H₁₄BrN₃O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.