TP3011

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TP3011

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

534605-74-8

CH0793011

TP3011 (CH0793011) 是 CH-0793076 的活性代谢产物 (metabolite)，是与 SN38 等价的有效拓扑异构酶 I (topoisomerase I) 抑制剂。TP3011 在 IC₅₀亚纳摩尔范围内可抵抗癌细胞系的生长。

生物活性

TP3011 (CH0793011) is an activemetaboliteof CH-0793076 and is a potent topoisomeraseI inhibitor equipotent as SN38^[1]. TP3011 is againstcancercell lines growth with IC₅₀s at the range sub-nanomolar in vitro^[2].

IC₅₀& Target^[1]

Topoisomerase I

体外研究
(In Vitro)

TP3011 (0-100 nM; 72 hours) (compound 6c) inhibits cell proliferative activities against various human cancer cell lines, producing 50% inhibition (IC₅₀) of cell growth of 0.85 nM; 8.5 nM; and 8.2 nM in HCT116, QG56, and NCI-H460 (NSCLC) cells, respectively^[2].

Cell Proliferation Assay^[2]

Cell Line:	HCT116, QG56, and NCI-H460 (NSCLC) cells
Concentration:	0-100 nM
Incubation Time:	72 hours
Result:	Was against human cancer cell lines, such as CRC and NSCLC cell lines.

分子量

474.51

Formula

C₂₆H₂₆N₄O₅

CAS 号

534605-74-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.