Topoisomerase II inhibitor 10

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CAS NO:

2488208-96-2

Topoisomerase II inhibitor 10 (compound 32a) 是一种有效的拓扑异构酶II (topoisomerase II) 抑制剂，IC₅₀为 7.45 μM。Topoisomerase II inhibitor 10 引起细胞周期阻滞在 G2-M 期，诱导 HepG-2 细胞凋亡 (apoptosis)。Topoisomerase II inhibitor 10 对 HepG-2、MCF-7 和 HCT-116 细胞具有良好的抗增殖活性。

生物活性

TopoisomeraseII inhibitor 10 (compound 32a) is a potenttopoisomeraseIIinhibitor with anIC₅₀value of 7.45 μM.TopoisomeraseII inhibitor 10 causes cell cycle arrest at G2-M phase and inducesapoptosisof HepG-2 cells.TopoisomeraseII inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells^[1].

IC₅₀& Target^[1]

Topoisomerase II

7.45 μM (IC₅₀)

分子量

572.55

Formula

C₂₇H₂₀N₆O₇S

CAS 号

2488208-96-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.