A1/A3 AR antagonist 1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

A1/A3 AR antagonist 1 (compound 10) 是一种有效的腺苷酸 1 (A1)和腺苷酸 3 (A3)受体双重拮抗剂，对人 A1、人 A3 和大鼠 A1 的K_i分别为 36.7 nM、25.4 nM 和 1.47 nM。A1/A3 AR antagonist 1 可用于肾衰竭、炎症性肺部疾病和阿尔茨海默症的研究。

生物活性

A1/A3 AR antagonist 1 (compound 10) is a potentadenosine 1 (A1)andadenosine 3 (A3)receptor dual antagonist withK_is of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease^[1].

IC₅₀& Target^[1]

human A1

36.7 nM (Ki)

rat A1

1.47 nM (Ki)

human A3

25.4 nM (Ki)

分子量

414.48

Formula

C₂₄H₁₈N₂O₃S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.