MIF-1

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MIF-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2002-44-0

Pro-Leu-Gly-NH2
Melanostatin

MIF-1 (Melanostatin) 是一种内源性的脑肽，是一种有效的多巴胺受体变构调节剂。MIF-1 抑制黑色素形成。MIF-1 阻断阿片受体激活的作用，从而调节吗啡的镇痛作用和应激诱导镇痛 (SIA)。MIF-1 直接通过血脑屏障 (BBB) 从血液进入中枢神经系统。

生物活性

MIF-1 (Melanostatin), an endogenous brain peptide, is a potentdopamine receptorallosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects ofopioid receptoractivation to modulate the analgesic effects of morphine and stress-induced analgesia (SIA). MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB)^[1]^[2]^[3].

体外研究
(In Vitro)

MIF-1 (Melanostatin, 1 μM) provokes a reversible hyperpolarization and a suppression of spontaneous action potentials^[2].

体内研究
(In Vivo)

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects of morphine and stress-induced analgesia (SIA)^[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats^[3].

Animal Model:	Male Wistar rats^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; once, for 1 hour
Result:	Decreased the analgesic effect of morphine. Increased the pain threshold for at least 1 h.

Animal Model:	Sprague-Dawley rats^[3]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; daily, for 8 weeks
Result:	Attenuated the ontogenic impairment of striatal D2 receptors that was produced byspiroperidol(HY-B1371) treatment.

分子量

284.35

Formula

C₁₃H₂₄N₄O₃

CAS 号

2002-44-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.