SKF 38393 ((±)-SKF-38393) hydrobromide 是一种 多巴胺 D1 受体 (dopamine D1 receptor) 的选择性激动剂,IC50值为 110 nM。
| 生物活性 | SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of thedopamine D1 receptor (D1DR)with anIC50of 110 nM[1]. |
| IC50& Target[1] | |
体外研究
(In Vitro) | SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].
Western Blot Analysis[2] | Cell Line: | GC cells | | Concentration: | 10 μM | | Incubation Time: | 1 hour | | Result: | Induced increased threonine-phosphorylation of DARPP-32 in cultured GC cells. |
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体内研究
(In Vivo) | SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
| Animal Model: | Balb/c mice (20-25 g)[3] | | Dosage: | 5 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
