Exendin(5-39)

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Exendin(5-39)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

196109-27-0

Exendin (5-39) 是一种强效的胰高血糖素样肽 1 (GLP-1 receptor) 受体拮抗剂。Exendin (5-39) 改善 β-淀粉样蛋白沉积的大鼠的记忆障碍。

生物活性

Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats^[1].

IC₅₀& Target

IC50: GLP-1 receptor^[1]

体内研究
(In Vivo)

Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG^[1].

Animal Model:	Wistar rats (3 weeks old and 18 days pregnant)^[1]
Dosage:	0.3 μg
Administration:	Intracerebroventricular injection; 0.3 μg; once daily; 1-week
Result:	Inhibited GLT-1 protein levels and inhibited long-term depression in rats.

分子量

3806.30

Formula

C₁₆₉H₂₆₂N₄₄O₅₄S

CAS 号

196109-27-0

Sequence

Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Sequence Shortening

TFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.