Glepaglutide

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Glepaglutide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

914009-86-2

ZP1848

Glepaglutide (ZP1848)，一种长效的 GLP-2 类似物，是一种有效的GLP-2R激动剂。Glepaglutide 可减少粪便排出量并增加肠道吸收。Glepaglutide 可减轻小肠炎症。Glepaglutide 可用于炎症性肠病 (IBD) 和克罗恩病的研究。

生物活性

Glepaglutide (ZP1848), a long-acting GLP-2 analogue, is a potentGLP-2Ragonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohn’s disease^[1]^[2]^[3].

IC₅₀& Target

GLP-2R^[3]

体内研究
(In Vivo)

Glepaglutide (200 and 400 nmol/kg, s.c., twice a day for 14 days) shows intestinotrophic effect in rats with small intestinal inflammation^[3].

Animal Model:	Rats withIndomethacin(HY-14397)-induced small intestinal inflammation^[3]
Dosage:	200 and 400 nmol/kg
Administration:	Subcutaneousinjection (s.c.), twice a day for 14 days.
Result:	Increased plasma citrulline concentration. Increased small intestinal mass. Decreased small intestinal concentrations of the inflammatory marker (AGP and MPO).

Clinical Trial

分子量

4316.08

Formula

C₁₉₇H₃₂₅N₅₃O₅₅

CAS 号

914009-86-2

Sequence

His-Gly-Glu-Gly-Thr-Phe-Ser-Ser-Glu-Leu-Ala-Thr-Ile-Leu-Asp-Ala-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Ala-Thr-Lys-Ile-Thr-Asp-Lys-Lys-Lys-Lys-Lys-Lys-NH2

Sequence Shortening

HGEGTFSSELATILDALAARDFIAWLIATKITDKKKKKK-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.