Ebselen Oxide

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Ebselen Oxide

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CAS NO:

104473-83-8

Ebselen oxide，Ebselen的硒酮类似物，通过共价修饰二鸟苷酸环化酶 (DGC) 以抑制 c-di-GMP 受体相互作用并降低 DGC 活性。Ebselen oxide 还抑制Pseudomonas aeruginosa产生藻酸盐 (alginate)，IC₅₀为 14 μM。Ebselen oxide 抑制 HDAC1、HDAC3、HDAC4、HDAC5、HDAC6、HDAC7、HDAC8 和 HDAC9 (IC₅₀范围为 0.2 至 4.7 μM)。

生物活性	Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC₅₀=14 μM) byPseudomonas aeruginosa. Ebselen oxide inhibitsHDAC1,HDAC3,HDAC4,HDAC5,HDAC6,HDAC7,HDAC8, andHDAC9(IC₅₀ranging from 0.2 to 4.7 μM)^[1]^[2]^[3].
体外研究 (In Vitro)	Ebselen oxide, is a covalent inhibitor of c-di-GMP allosteric binding to I-site containing proteins, diguanylate cyclase (DGC) activity^[1]. Ebselen oxide inhibits diguanylate cyclase from synthesizing c-di-GMP. Ebselen oxide exhibits increased potency on HDAC8 (IC₅₀=0.2 μM) in comparison with Ebselen^[3].
分子量	290.18
Formula	C₁₃H₉NO₂Se
CAS 号	104473-83-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.