BI 703704

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BI 703704

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

BI 703704 是一种有效的可溶性鸟苷酸环化酶(sGC)激活剂。BI 703704 抑制 ZSF1 大鼠的糖尿病肾病的进展。

生物活性

BI 703704 is a potentsolubleguanylate cyclase(sGC)activator. BI 703704 inhibits the progression of diabetic nephropathy in the ZSF1 rat^[1].

体内研究
(In Vivo)

BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) results in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content^[1].
BI 703704 is effective in elevating renal cGMP levels in a dose-dependent manner and in slowing the progression of diabetic nephropathy in an oxidative stress milieu^[1].

Animal Model:	Fifty-eight male ZSF1 rats (12-13 weeks)^[1]
Dosage:	0.3, 1, 3, or 10 mg/kg
Administration:	Food intake; daily for 15 weeks
Result:	Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content.

分子量

559.72

Formula

C₃₂H₃₇N₃O₄S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.