Olsalazine

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Olsalazine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

15722-48-2

Olsalazine 是巨噬细胞趋化LTB4的有效抑制剂，IC₅₀为0.39 mM，还可减少多形核白细胞 (PMNL) 和单核细胞 (MNL) 中 5-HETE、11-HETE、12-HETE 和 15-HETE的合成。Olsalazine 可用于溃疡性结肠炎的研究，具有抗炎活性。

生物活性

Olsalazine is a potent inhibitor of macrophages chemotaxis toLTB4with anIC₅₀value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity^[1]^[2].

IC₅₀& Target

IC₅₀: 0.39 mM (LTB4)^[1]

Clinical Trial

分子量

302.24

Formula

C₁₄H₁₀N₂O₆

CAS 号

15722-48-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.