CAY10583

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CAY10583

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

862891-27-8

CAY10583 是一种有效的、选择性的全白三烯 B4 受体 2 型 (BLT2) 激动剂。CAY10583 在体外直接促进角质形成细胞迁移，可加速伤口愈合。CAY10583 有潜力用于糖尿病创面药物的研究。

生物活性

CAY10583 is a potent and selective full Leukotriene B4 receptor type 2 (BLT2) agonist. CAY10583 directly promotes keratinocyte migrationin vitroand accelerates wound closurein vivo. CAY10583 is a promising pharmaceutical agent for diabetic wounds^[1].

IC₅₀& Target^[1]

LTB₄

体外研究
(In Vitro)

CAY10583 (1 nM-1μM; 24 hours) promotes wound closure via keratinocyte migration. And CAY10583 has no significant effect of on keratinocyte proliferation^[1].

体内研究
(In Vivo)

CAY10583 (administered topically to full-thickness wounds; 10 μM; 14 days) significantly results in a greater wound closure than the control group. The difference in wound closure between the CAY-treated group and the control group is pronounced over time until day 10. And the difference is approximately 6% at day 4 and reaches almost 20% at day 8. Notably, 100% closure was observed in the CAY-treated group at day 14^[1].

Animal Model:	Lewis rats (6-9 weeks of age, 180-220 g)^[1]
Dosage:	10 μM; 14 days
Administration:	Administered topically to full-thickness wounds; 10 μM; 14 days
Result:	Acceleratedin vivowound healing by topical application.

分子量

387.47

Formula

C₂₅H₂₅NO₃

CAS 号

862891-27-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.