CP-96021 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

167011-22-5

CP-96021 hydrochloride 是一种平衡，有效的口服活性白三烯 D4 (LTD4)/血小板活化因子 (PAF) 受体拮抗剂，K_i值分别为 34 nM 和 37 nM。

生物活性

CP-96021 hydrochloride is a balanced, combined, potent and orally activeleukotriene D4 (LTD4)/platelet activating factor (PAF)receptor antagonist withK_ivalues of 34 nM and 37 nM, respectively^[1].

IC₅₀& Target^[1]

LTC₄

34 nM (Ki)

Platelet activating factor (PAF) receptor

37 nM (Ki)

体内研究
(In Vivo)

In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs withED₅₀s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with anED₅₀s of 1.8 mg/kg p.o^[1].

分子量

529.03

Formula

C₂₉H₂₂ClFN₄OS

CAS 号

167011-22-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.