LTD4antagonist 1 是一种有效有效的白三烯 D4(leukotriene D4,LTD4) 拮抗剂，Ki值为 0.57 nM。
| 生物活性 | LTD4antagonist 1 is a potent, orally active antagonist ofleukotriene D4(LTD4) with aKiof 0.57 nM. |
| IC50& Target[1] | |
体外研究
(In Vitro) | LTD4antagonist 1 (Compound 38b) exhibits a Kiof 0.57 nM for displacement of [3H]LTD4on guinea pig lung membranes, a pKBof 9.93±0.14 versus LTE4on guinea pig trachea[1].
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体内研究
(In Vivo) | LTD4antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
