12S-HHT

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12S-HHT

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CAS NO:

54397-84-1

12(S)-HHTrE

12S-HHT (12(S)-HHTrE) 是前列腺素 H₂(PGH₂) 的酶促产物，来源于环氧化酶 (COX) 介导的花生四烯酸代谢。12S-HHT 是BLT2的内源性配体，在体内完全激活BLT2。12S-HHT 抑制紫外线诱导的角质形成细胞中 IL-6 的合成，发挥抗炎活性。

生物活性

12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H₂(PGH₂) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand forBLT2that fully activatesBLT2in vivo. 12S-HHT suppresses UV-inducedIL-6synthesis in keratinocytes, exerting an anti-inflammatory activity^[1]^[2].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

12S-HHT (0-150 nM; 3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells^[2].
12S-HHT inhibits the UVB-stimulated p38 MAPK/NF-κB pathway by up-regulating MKP-1, which leads to the suppression of IL-6 synthesis^[2].
12S-HHT is an endogenous agonist for BLT2^[3].

Western Blot Analysis^[2]

Cell Line:	HaCaT cells
Concentration:	0, 12.5, 25, 75 or 150 nM
Incubation Time:	3 hours
Result:	UVB (5 mJ/cm2) irradiation markedly up-regulated IL-6 synthesis and release, which was suppressed by the treatment with 12-HHT in a concentration-dependent manner.

分子量

280.40

性状

Liquid

Formula

C₁₇H₂₈O₃

CAS 号

54397-84-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years