IMMH001

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IMMH001

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1418093-75-0

IMMH001，也被称为 SYL930，是一种口服有效的选择性的S1P1(鞘氨醇 -1- 磷酸受体 1) 激动剂。IMMH001 可降低趋化因子和促炎细胞因子的水平，包括 IL-1β、IL-5、IL-18、IP10、CCL3 和 CCL5。IMMH001 可用于类风湿关节炎(RA)的研究。

生物活性

IMMH001, also called SYL930, is an orally active, potent and selectiveS1P1(sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β,IL-5,IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research^[1]^[2].

IC₅₀& Target

S1PR1

体内研究
(In Vivo)

IMMH001 is converted to the active form, its monophosphate ester (S)-IMMH001-P, by sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2)in vivo^[1].
IMMH001 suppresses both Th1 cell (IL-1β, IL-18, and IP10) and Th2 cell (IL-5)-mediated disease reactions in damaged joints^[2].
IMMH001 (0.3-2.4 mg/kg, Orally; twice a week, for 28 days, AA rats; for 30 days, CIA rats) relieves the damage of AA (adjuvant-induced arthritis) and CIA (collagen-induced arthritis) rats’ joints^[2].

分子量

380.48

Formula

C₂₃H₂₈N₂O₃

CAS 号

1418093-75-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.