LPA2 antagonist 2

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LPA2 antagonist 2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

36840-10-5

LPA2 antagonist 2 是一种选择性LPA₂拮抗剂，IC₅₀为 28.3 nM，K_i为 21.1 nM，比 LPA₃(IC₅₀为 13.85 μM) 选择性高 480 倍以上。

生物活性

LPA2 antagonist 2 (H2L 5226501) is a selectiveLPA₂antagonist with anIC₅₀of 28.3 nM and aK_iof 21.1 nM. LPA2 antagonist 2 is >480-fold more selective than LPA₃(IC₅₀of 13.85 μM)^[1].

IC₅₀& Target

IC50: 28.3 nM (LPA₂); 13.85 μM (LPA₃)^[1]

体外研究
(In Vitro)

Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA₁with an Imax of 59.0% at 30 μM^[1].

分子量

380.35

性状

Solid

Formula

C₂₀H₁₆N₂O₆

CAS 号

36840-10-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 83.33 mg/mL(219.09 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.6292 mL	13.1458 mL	26.2916 mL
5 mM	0.5258 mL	2.6292 mL	5.2583 mL
10 mM	0.2629 mL	1.3146 mL	2.6292 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。