ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) ofM₁mAChR, with anEC₅₀of 1.38 μM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease^[1].

EC₅₀: 1.38 μM (M1 mAChR)^[1]

ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M₁–M₅^[1].
ML169 shifts APP processing towards a non-amyloidogenic pathway^[1].
ML169 (2 μM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 μM CCh^[1].

ML169 (VU0405652) (10 mg/kg; i.p.) affords a brain_AUC/plasma_AUCof 0.32 at 1 h in rats^[1].

506.34

C₂₁H₁₇BrFN₃O₄S

1222878-02-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.