Atropine hydrobromide

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CAS NO:

6415-90-3

Tropine tropate hydrobromide
DL-Hyoscyamine hydrobromide

Atropine (Tropine tropate) hydrobromide 是一种竞争性的毒碱乙酰胆碱受体 (mAChR) 拮抗剂，拮抗 Human mAChR M₄和 Chicken mAChR M₄的IC₅₀值分别为 0.39 nM 和 0.71 nM。Atropine hydrobromide 抑制 ACh 诱导的人肺静脉松弛。Atropine hydrobromide 可用于抗近视和心动过缓研究。

生物活性

Atropine (Tropine tropate) hydrobromide is a competitivemuscarinic acetylcholine receptor(mAChR)antagonist withIC₅₀values of 0.39 and 0.71 nM for HumanmAChRM₄and ChickenmAChRM₄, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia^[1]^[2]^[3]^[4].

IC₅₀& Target

IC50: 0.39 nM (Human mAChR M4) and 0.71 nM (Chicken mAChR M4)^[3]

体外研究
(In Vitro)

Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) hydrobromide inhibits ACh-induced relaxations in human pulmonary veins^[4].

体内研究
(In Vivo)

Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes;Peromyscussp.) hydrobromide inhibits the cardiac arrhythmia which normally occurs throughout torpor^[2].

Animal Model:	White-footed mice (Peromyscussp.)^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; once, for 40 minutes
Result:	Increased heart rate was a decrease in cardiac arrhythmia.

Clinical Trial

分子量

370.28

Formula

C₁₇H₂₄BrNO₃

CAS 号

6415-90-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.