Methacholine bromide

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CAS NO:

333-31-3

Acetyl-β-methylcholine bromide

Methacholine (Acetyl-β-methylcholine) bromide 是一种有效的muscarinic-3 (M3)激动剂。Methacholine bromide 直接作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。Methacholine bromide 对识别支气管高反应性 (BHR) 显示出高灵敏度。Methacholine bromide 可用于测量气道高反应性 (AHR)，作为评估具有哮喘样症状和正常静息呼气流速的个体的诊断辅助^[2]。

生物活性

Methacholine (Acetyl-β-methylcholine) bromide is a potentmuscarinic-3 (M3)agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates^[1]^[2]^[3]^[4].

体内研究
(In Vivo)

Methacholine bromide (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs^[4].
Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse^[5].

Animal Model:	9-week female BALB/c mice^[6]
Dosage:	0.03, 0.1, 0.3, 1 mg/kg
Administration:	I.v
Result:	Induced severe bronchoconstriction.

Clinical Trial

分子量

240.14

Formula

C₈H₁₈BrNO₂

CAS 号

333-31-3

中文名称

溴化乙酰甲胆碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.